Numerous brain disorders can be associated basal ganglia dysfunction, including Parkinson's disease, Huntington's disease, progressive supranuclear palsy, corticobasal degeneration, multiple system atrophy, Wilson disease, and dystonia. In addition, any insult to the brain can potentially damage the basal ganglia including strokes, metabolic abnormalities, liver disease, multiple sclerosis, infections, tumors, drug overdoses or side effects, and head trauma.
When the basal ganglia are damaged, control over functions such as speech and movement may be impaired. Difficulties with starting movement, sustaining movement and stopping movement are all possible when this area is injured.
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