Primary myelofibrosis

Injury	Disease	Nutrition	Poison

Symptoms	Surgery	Test	Special Topic

Overview

Symptoms

Treatment

Prevention

Primary myelofibrosis

Alternative Names:

Myelofibrosis; Idiopathic myelofibrosis; Myeloid metaplasia; Agnogenic myeloid metaplasia

Symptoms:

Fatigue
Abdominal fullness related to an enlarged spleen
Easy bleeding
Bone pain
Pallor (paleness)
Shortness of breath on exertion
Bruising
Increased susceptibility to infection

Signs and tests:

Physical examination shows an enlarged spleen. Later in the disease, it may also show an enlarged liver.

An examination of the blood shows teardrop-shaped red blood cells.
The white blood cell count is variable.
The platelet count is variable.
Bone marrow biopsy may be performed to rule out other causes of the symptoms.
CBC (complete blood count) shows a low red blood cell count.

Review Date: 4/15/2005
Reviewed By: Rita Nanda, MD, Department of Medicine, Section of Hematology/Oncology, University of Chicago Medical Center, Chicago, IL. Review provided by VeriMed Healthcare Network.

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