 |
 |
  Familial hypertriglyceridemiaDefinitionFamilial hypertriglyceridemia is a common inherited disorder in which the level of triglycerides (a type of fat) in a person's blood are higher than normal. The condition is not associated with a significant increase in cholesterol levels. CausesFamilial hypertriglyceridemia is caused by a genetic defect, which is passed on in an autosomal dominant fashion. This means that if you get a bad copy of the gene from just one of your parents, you will have the condition. Some people with this condition also have high levels of very low density lipoprotein (VLDL). The reason for the rise in triglycerides and VLDL is not understood. Familial hypertriglyceridemia does not usually become noticeable until puberty or early adulthood. Obesity, hyperglycemia (high blood glucose levels), and high levels of insulin are frequently associated with this condition and make cause even higher triglyceride levels. Familial hypertriglyceridemia occurs in about 1 in 500 individuals in the United States. Risk factors are a family history of hypertriglyceridemia or a family history of heart disease before the age of 50. Symptoms
Exams and Tests
TreatmentThe goal of treatment is to control conditions that can raise triglyceride levels, such as obesity, hypothyroidism, and diabetes. Patients may be told not to drink alcohol. The use of birth control pills (oral contraceptives) should be reviewed and the specific type chosen carefully. People with this condition should avoid excess calories and foods high in saturated fats and carbohydrates. If high triglyceride levels persist despite diet changes, medication may be needed. Nicotinic acid and gemfibrozil have been shown to effectively reduced triglycerides in those with familial hypertriglyceridemia. Outlook (Prognosis)People with this condition have an increased risk of coronary artery disease and pancreatitis. Losing weight and keeping diabetes under control helps improve a person's outcome. Possible Complications
PreventionScreening family members for high triglycerides may detect the disease early.
Review Date:
5/31/2006 Reviewed By: Brian Kirmse, MD, Mount Sinai School of Medicine, Department of Human Genetics, New York, NY. Review provided by VeriMed Healthcare Network. The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997-
A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.  |
